Publication:

Cyclopia-holoprosencephaly sequence: a rare entity

Cyclopia is a congenital disorder, a rare form of holoprosencephaly, characterized by the failure of embryonic prosencephalon to properly divide the orbits of the eye into two cavities with grossly incomplete morphogenesis of fore brain. The severity has a marked variability and ranges from cyclopia to minimal craniofacial dysmorphism, such as microcephaly with a single central incisor. Reports of this anomaly are few and because of the rarity, the present case is being reported.