Publication:

Skin: mirror of marrow- case of POEMS syndrome

Monoclonal gammopathy is clonal proliferation and accumulation of immunoglobulin producing B-cells. A variety of skin disorders are associated with an increased level of monoclonal immunoglobulin proteins. Synonyms such as monoclonal gammopathies, paraproteinemias, plasma cell dyscrasias and dysproteinemias are used to designate gammaglobinopathies. Here in we report a case of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome presenting with sclerodermoid features.