Publication:

Nephroprotective effect of ethanolic extract of abutilon indicum root in gentamicin induced acute renal failure

Background The term acute renal failure (ARF) is at present called acute kidney injury (AKI). AKI is a reversible condition in which there is a sudden decline in renal function, manifested by elevated SCr and BUN which occurs in hours to days to weeks. The present study was to evaluate the nephron protective effect of abutilon indicum root in gentamicin induced acute renal failure in wistar albino rats.

Methods Experimental evaluation was done in gentamicin induced acute renal failure. 24 rats were divided into 6 in each group. Group 1 was given normal saline (10 ml/kg) per oral, group 2 with gentamicin (100 mg/kg, ip for 5 days), group 3 with gentamicin and extract 150 mg/kg and, group 4, gentamicin and extract 300 mg/kg and group 5, extract 300 mg/kg. The dose of the extract was given orally 60 min prior to gentamicin injection. The duration of the study was for 7 days all the doses are given once a day for 7 days. 24 urine output, serum creatinine (SCr), blood urea nitrogen (BUN), total proteins and albumin were measured at end of the day for all the groups. Kidneys were examined for histopathological changes.

Results Animals treated with extract showed significant improvement in biochemical parameters and histopathological changes compared to group II animal as treated with gentamicin. The protective effect was highly significant the dose of 300 mg/kg of extract.

Conclusions The ethanolic extract of abutilon indicum root has nephron protective effect in gentamicin induced acute renal failure. Nephro protective action in this study could be due to the antioxidant and other phytochemical of abutilon indicum root.