Publication:

The perinatal and maternal outcome in pregnancy with advanced maternal age 35 years and >35 years

Background Purpose of this study is to evaluate maternal and perinatal outcome in advanced maternal age women. As numbers of pregnancies in advanced maternal age continue to grow, obstetric care provider would benefit from up to date outcome data to enhance their preconceptional and antenatal counseling.

Methods It is observational prospective analytic study, conducted in Nowrosjee Wadia maternity hospital, Parel, Mumbai. Total 100 patients were included in study, fulfilling inclusion criteria over period of 1 year.

Results In 100 patients, most common cause of delay conception is infertility (27%). 24% of patients conceived after treatment. out of 100 patients 23% of patients had pre-existing medical and surgical disorders, 50% developed complications in pregnancy. Out of 100 patient 58 patients undergone through biochemical study, 3 patients had high risk for chromosomal disorders. The rate of caeasarean section in our study is 68%. Perinatal mortality and morbidity is high in our study, rate of preterm delivery is 23.7%. Out of 105 babies (including multiple gestation), 42.8% babies are low birth weight out of which 9.5% babies are very low birth weight. Rate of NICU admission is 33%, perinatal mortality rate, neonatal mortality rate and still birth rate is 19.4 per 1000 births. Advanced maternal age is related to high maternal and perinatal morbidity and mortality rate.

Conclusions Pregnancies in women of advanced maternal age are considered high risk for Perinatal and maternal morbidity and mortality. A proper preconception consultation and intensive antenatal care assessment can individualize and potentially reduce the risks for women with advanced maternal age.