Publication:

Impact of organoleptic properties on pediatric antibiotic compliance: a comparative study of three commonly prescribed co-amoxyclav suspensions in India

Background Palatability is a crucial factor influencing adherence of medication in pediatric populations, especially for oral antibiotic suspensions. This study aimed to evaluate and compare the organoleptic properties of three co-amoxyclav 457 mg formulations: Product A (Advent), Product B (Comparator 1) and Product C (Comparator 2) in 55 healthy school-going children aged 6 to 9 years.

Methods Each product was administered at 15–20-minute intervals and responses were recorded using a structured questionnaire that included behavioural analysis, taste discrimination, ranking and compliance perception.

Results Product A showed the highest acceptability, with 94.5% of children displaying favourable facial expressions and 100% accepting the product. Based on taste, 91% rated product A as excellent or good, compared to 67% for product B and 82% for product C. Additionally, 85% of participants described product A’s taste as sweet, with a fruity orange aftertaste. Smell ratings were also highest for Product A, with 89% rating it excellent or good, versus 71% for product B and 73% for product C. Regarding aftertaste, 78% found product A sweet, while about 55% found products B and C sweet. Overall, 57% of children preferred product A and more than 90% assured they would complete the course if prescribed this formulation.

Conclusions These findings highlight the importance of organoleptic properties in pediatric antibiotic formulations. By considering organoleptic properties during prescribing, healthcare providers can significantly enhance adherence, leading to improved treatment outcomes and a reduced risk of antimicrobial resistance.