Publication:

Prevalence and drug susceptibility pattern of Shigella and Salmonella species in under ten diarrhoeic children admitted to Tirunesh-Beijing hospital

Background Diarrheal diseases constitute a major burden of disease in the low and middle-income countries of the world with diarrhea being the second leading cause of morbidity. Now a day, food borne disease, caused by Shigella and Salmonella species is the most common type of bacterial gastroenteritis  have gained multiple antimicrobial resistances; the challenge for clinical management. For acute childhood diarrhea that requires antimicrobial therapy correct choice of the drug depends on detailed previous knowledge of local strains. Therefore, the objective of the study was to assess the prevalence and drug susceptibility pattern of diarrheal diseases in under 10 children admitted to Tirunesh-Beijing hospital to provide preliminary information for healthcare providers.

Methods Selective and differential media for isolation of diarrhea causing bacterial species was used. Further biochemical tests were conducted to confirm the results. The drug sensitivity and resistance pattern of isolated bacteria was assessed by minimum inhibitory concentration (MIC) as well as minimum bactericidal concentration (MBC). Data about patients' sex and age, pathogens isolated and their antimicrobial resistance patterns were recorded.

Results Out of 22 stool samples collected from diarrhoeic under ten children the majority was males. Two (9.1%) stool samples were found positive for one Shigella sonnei and one Shigilla flexnrei while no Salmonella species was identified.

Conclusions The isolated Shigella species showed high antibiotic resistance to amoxicillin, cotrimoxazole and ampicillin. But it was susceptible to ciprofloxacin. Therefore, frequent assessment of the pattern of resistance and prevalence is needed to keep the community save and use appropriate drug for treatment in the study area.