Publication:

Assessment of oral hypoglycaemic activity of water soluble extract of aloe vera and its interaction with glipizide in alloxan induced diabetic Wistar Rats

Background Assessment of oral hypoglycaemic activity of water soluble extract of Aloe vera and its interaction with Glipizide in Alloxan induced diabetic Wistar rats.

Methods Under standard condition of testing, alloxan induced diabetic rats were kept in fasting state of 8 hours and then glucose in dose of 1gm/kg was given PO by feeding tube. There after water soluble extract of aloe vera in dose of 200mg/kg BW dissolves in 1ml of Distilled water (DW) to test group 1, Glipizide in dose of 2.5mg/kg BW dissolved in 1ml DW was given to standard group. Test group 2 received combination of Aloe vera 200mg/kg BW and Glipizide in dose of 2.5mg/kg BW dissolved in 1ml Dw. Control group received 1ml of Distilled water. Blood sugars levels of all Rats in each group were checked with Glucometer.

Results Clinically and statistically significant glucose lowering effect was observed in groups administered with Aloe vera and better results were observed in group receiving Aloe vera and Glipizide combination.

Conclusions Water soluble extract of aloe vera has significant hypoglycaemic activity and the results showed that co-administration of Aloe vera and Glipizide has superior hypoglycaemic activity compared to Aloe vera and Glipizide given Individually.