Publication:

Evaluation of lipid profile and apolipoproteins in cord blood from Tribal and nontribal population of Udaipur region, India

Background Cardiovascular diseases are the leading cause of mortality in India. The important factor associated is dyslipidemia. A strong relationship has been seen in epidemiological studies between cholesterol and cardiovascular disease. The present study was planned to analyze cord blood lipid profile, apolipoproteins and atherogenic index in tribal and nontribal population and compare them gender wise.

Methods Our study group consisted of 250 healthy full-term newborn. The cord blood was collected immediately after a normal delivery. The blood was tested to determine lipid profile, apolipoproteins and atherogenic index.

Results The results showed that the levels of lipid profile, apolipoproteins and ratio (TC/HDL, TC/LDL, HDL/LDL, and LDL/HDL) were higher in non-tribal population than tribal ones. Gender wise comparison revealed higher levels in male non-tribal neonates as compared to female non-tribal neonates. The apolipoproteinB and Atherogenic index (ApoB/ApoA-1) were higher in females than male non-tribal neonates in cord blood. The trends were reversed in the tribal population.

Conclusions The result concluded that tribal and non-tribal population, also female and male neonates have genetic variation and difference in lipid metabolism.