Publication:

Effect of intravenous tranexamic acid in reducing blood loss during and after caesarean section: a quasi-experimental study in RIMS, Manipur

Background PPH is the most common cause of maternal death worldwide. Risk factors for PPH include grand multiparity and multiple gestation. However, PPH may occur in women without identifiable clinical or historical risk factors. It is therefore recommended that active management of the third stage of labour be offered to all women during childbirth, whenever a skilled provider is assisting with the delivery. The aim of our study is to determine the efficacy of tranexamic acid in decreasing blood loss in elective LSCS. Materials: A quasi experimental study was done in 312 pregnant women undergoing elective LSCS in the Department of Obstetrics and Gynaecology, at a tertiary health teaching centre RIMS, Imphal, Manipur from September 2019 to November 2021. Ethical clearance was obtained from Research ethics Board to carry out the study. Data were entered in IBM SPSS version 21 software for Windows.

Results The total of 312 pregnant women were included in the study. Most of the pregnant women were in the age group of 27 years. In our study, there was a significant decrease in intraoperative and postoperative blood loss in women receiving tranexamic acid. There was significant fall in post-operative haemoglobin in control group as compared to study group. Also, women who received tranexamic acid did not develop any significant complications.

Conclusions Tranexamic acid can be used safely as a prophylaxis to reduce blood loss during caesarean section.