Publication:

Comparison of clinical profile and in hospital outcome of acute kidney injury in diabetic and non-diabetic hospitalized patients in tertiary care hospital: a prospective observational analytical study

Background Diabetic and non-diabetic patients experience AKI of variable severity. Not much data exists about the comparison between these two with follow-up of the renal recovery. We here describe this study for bridging the knowledge gap.

Methods Diabetic and non-diabetic patients having AKI were identified during the study period (n=66 each) at AIIMS Rishikesh in prospective manner. Patients were followed up and results were compared till the period of hospitalization.

Results In Demographics, Diabetic patients were more in middle age (p-value-<0.001). diabetic patients had more underlying CKD than non-diabetic (p value-<0.001). severity of AKI, RRT requirement and outcomes were comparable in both groups. Out of 132, only 4 patients (3 diabetics and 1 non-diabetic) had mortality. Overall, AKI and its outcomes and mortality are comparable in diabetic and non-diabetic patients.

Conclusions Primary objective being the in-hospital mortality rates is comparable between two groups and so is the need of renal replacement therapy and renal recovery at discharge. Most of the diabetic patients experiencing AKI episodes were in middle age to elder group, while non-diabetics have more of young and middle age predominance difference between them were statistically significant. In terms of AKI episodes, difference of prevalence of CKD and hypertension was more in diabetic group (p value <0.001).