Publication:

An observational study to assess the drug prescription pattern and quality of life of acne vulgaris patients in a tertiary care center in India

Background The study was conducted to assess the prescription pattern of acne vulgaris patients, and impact of anti-acne treatment on severity of acne and change in quality of life (QoL) in patients.

Methods A prospective observational study was conducted in dermatology OPD of a tertiary care hospital with 160 patients of acne vulgaris. All patients with acne vulgaris >18 years, of either sex were included while those with pre-existing other cutaneous or systemic diseases, pregnant and lactating females and not giving consent were excluded from the study. Prescriptions were analysed and patients were followed-up at 2 and 6 weeks for assessment of change in acne severity and QoL, determined by GAGS score and CADI difference score, respectively.

Results Mean age of patients was 20.7±2.5 years, with males and females constituting 62 (38.8%) and 98 (61.3%) patients, respectively. Acne was mild in 88 (55%), moderate in 51 (31.9%) and severe in 21 (13.1%) patients. A total of 537 drugs were prescribed to all patients, with an average of 3.36 drugs per prescription. Two, 3 and 4 drugs were prescribed in 2.5%, 59.4% and 38.1% patients, respectively. There was significant improvement in the GAGS score (p<0.001) and QoL (CADI score difference) (p<0.001) at 2 and 6 weeks follow-up compared to initial visit.

Conclusions Polypharmacy was a common practice in anti-acne treatment. However, it was associated with improvement in acne severity and QoL.