Original Research ArticleInternational Journal of Basic & Clinical Pharmacology
Publication: Comparative study of assay of free radical damage in in vivo, in vitro and ex vivo conditions
Int J Basic Clin Pharmacol. 2014;3(2):308-314.DOI10.5455/2319-2003.ijbcp20140411
Abstract
Background Interception of free radical events and damage in clinical situation remain arbitrary with poor understanding on antioxidant pharmacology.
Methods Experiments on in vitro per-oxidation insult as well as assumed free radical damage situation in ischemia reperfusion are examined for profile of malondialdehyde rise and effect of Gikgobiloba treatment by different schedule.
Results Effect of Ginkgobiloba was seen on ischemia reperfusion induced, hydrogen peroxide induced and ferric chloride induced methods. Antioxidant effect of Ginkgobiloba was consistent in all techniques.
Conclusions Results reveal the significance of complementary experiment to elaborate issue of antioxidants.
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Affiliations
- Department Pharmacology,Institute of Medical Sciences,Banaras Hindu University,Varanasi - 221 005,Uttar Pradesh,India
- Department of Biochemistry,Institute of Medical Sciences,Banaras Hindu University,Varanasi - 221 005,Uttar Pradesh,India
- School of BiochemicalEngineering, Indian Institute of Technology, Banaras Hindu University, Varanasi - 221 005,Uttar Pradesh, India