Publication:

Correlation of prothrombin time and activated partial thromboplastin time with serum immunoglobulin and M-band in newly diagnosed multiple myeloma patients

Background Multiple myeloma is the second most frequent malignancy which constitute 13% of hematologic cancers. Thrombotic and hemorrhagic complications have been frequently observed in multiple myeloma patients.

Methods The study was conducted in the department of pathology, Government medical college Srinagar. A total of fifty (50) patients were recruited for the study. The patients were advised coagulation profile and complete myeloma profile.

Results Our findings indicate that prolonged PT is associated with high serum IgG levels. A mild to moderate correlation was seen with kappa-free light chains and an inverse correlation was seen between PT and lmbda-free light chains.

Conclusions Screening of multiple myeloma for hemostatic abnormalities at the diagnosis should improve prognosis in such cases.