Publication:

To compare the efficacy of Drotaverine hydrochloride and Valethamate bromide in shortening of the first stage of labour

Background To compare the efficacy of Drotaverine Hydrochloride and Valethamate Bromide in shortening of the first stage of Labor. Drotaverine is more effective in regards of shorten the 1st stage of labor, rate of cervical dilatation with less side effects in compare to Valethamate Bromide.

Methods Two Hundred demographically similes woman with full term pregnancy in active labour were included in the study and divided into two groups viz.First Group: 100 women were given injection Drotaverine Hydrochloride (Drotin) 40 mg intramuscularly at 3-4 cm dilation at two hour interval.Second Group: 100 women were given injection Valethamate Bromide Intramuscularly at 3-4 cm dilation at one hour interval.Maximum three injections were given in both the groups. Comparative analysis was carried out as regards to duration of various stages of labor, rate of cervical dilatation, mode of delivery, side effects and feto-maternal outcome.

Results In Group-I Average duration of active phase of first stage of labor was 149.78 minutes. In Primigravida it was 170.22 minutes and 129.35 minutes in Multigravida.In Group II Average duration of active phase of first stage of labor was 294.62 minutes.In Primigravida it was 321.71 minutes and 267.54 minutes in Multigravida.Average rate of cervical dilatation in Group-I was 2.81cm/hour. In Primigravida it was 2.50 cm/hour while in Multi gravid it was 3.33cm/hour.In Group-II average rate was 1.42 cm/hour, in Primigravida it was 1.30 cm/hour and in Multigravida1.57 cm/hour.

Conclusions Drotaverine significantly shorten the duration of first stage of labor and found to be safe with no adverse effect on the mother and fetus.