Publication:

A comparative study of intravenous dexmedetomidine and midazolam on prolongation of spinal anesthesia

Background The present study was conducted to compare the efficacy and safety of intravenous dexmedetomidine and midazolam on prolongation of spinal anesthesia.

Methods The study population included people who were undergoing for spinal anesthesia for various surgeries. A total of 90 subject were randomized equally to Dexmedetomidine, Midazolam and saline groups using a computer generated random number sequence. Three study groups were compared with respect to all the baseline variables. The key outcome parameters and hemodynamic parameters were compared among the three study groups.

Results No statistically significant differences were observed in baseline paramters across study groups. The median values of patient satisfaction score and anesthesiologist satisfaction score were almost equal among three study groups, but the association was statistically not significant. The median VAS and the median HSL were slightly lower in dexmedetomidine group than other two groups (VAS-1,2,3 respectively and HSL -4,6,6 respectively) with statistically significant association (P 0.05) except with number of patients requiring analgesic for the first 24 hours (P value<0.05).

Conclusions Measurement of patient and anesthesiologist satisfaction scores are more or less similar in midazolam and dexmedetomidine groups compare to saline group.