Publication:

Association of metabolic syndrome and endometrial pathologies in postmenopausal women

Background The menopausal state may predispose the women to the development of metabolic syndrome as its prevalence has been reported to increase after the attainment of menopause. The aim of this study was to determine the prevalence of metabolic syndrome and its components in post-menopausal women and to assess the association between metabolic syndrome and endometrial pathologies in post-menopausal women.

Methods An observational study conducted at gynecology OPD of GSVM Medical College, Kanpur and Total 80 post-menopausal women who had history of at least 1 year cessation of menses.

Results Endometrial pathology was present in 63.2% of patients with metabolic syndrome and in 38.1% of patients without metabolic syndrome. The association between endometrial pathology and metabolic syndrome was found to be statistically significant (p=0.025). The highest incidence was found for fasting glucose (86.8%) followed by blood pressure (81.5%), high triglycerides (81%), low HDL (60.5%), and waist circumference (23.6%). Waist circumference, triglyceride, HDL, diabetes, waist circumference had postulated to be predictors for endometrial pathology.

Conclusions Endometrial cancer is a type of metabolic syndrome-related tumor. Elucidating the specific roles and the possible mechanisms of metabolic syndrome in pathogenesis of endometrial cancer is expected to provide a new target for the early prevention and treatment of endometrial cancer.