Publication:

Association between lipid profile and silent coronary artery disease in south Indian patients with type 2 diabetes mellitus

Background The patients with type 2 diabetes have an increased prevalence of lipid abnormalities (Dyslipidemia). Early diagnosis of diabetic patients with silent CAD and dyslipidemia can reduce the morbidity and mortality for cardiovascular death. The objective of the present study is to assess the prevalence of silent coronary disease among south Indian type-2 diabetic patients without cardiovascular symptoms and association between lipid profile and silent coronary disease among them.

Methods 100 Type 2 diabetes mellitus patients (65 males and 35 females) of age 40-80 years attending the OPD of Sri Siddhartha Medical College, Tumakuru, Karnataka, Indiawere enrolled in this study. The Serum samples were analysed for fasting blood glucose (FBS), post prandial blood glucose (PPBS), HbA1c, and lipid profile. The patients were classified into CAD and Non CAD groups based on ECG changes and stress test. Results were analysed SPSS 16.0 software.

Results The study revealed that 46% of our study population had silent CAD. The prevalence of dyslipidemia was found higher in males than females in both study groups. CAD group patients had significantly higher levels of serum total cholesterol, triglycerides, LDL- cholesterol and low HDL - cholesterol compared to Non CAD group.

Conclusions Dyslipidemia is indicating the strong association with silent CAD in type 2 diabetes mellitus. It is also advisable to have a screening ECG for silent CAD at the time of diagnosis or during the follow-up period in type 2 diabetes.