Publication:

Derangement in lipid profile in nephrotic syndrome in children

Background Hyperlipidemia, an important characteristic of idiopathic nephrotic syndrome in children (NS),thereby makes them prone to develop premature atherosclerosis and related complications.

Methods We have investigated the changes in different fractions of lipids and apolipoproteins level in thirtychildren of 1-12 years of age with idiopathic nephrotic syndrome. Twenty-six age and sex matched hospitalizedchildren, suffering from non-renal diseases, were enrolled as controls.

Results The results revealed that ApoB along with cholesterol, triglyceride and LDL-cholesterol, were significantly increased (p<0.001), whereas apoA1 and HDL-cholesterol were unaltered in the patients compared to the controls. Further, the ratios cholesterol: HDL-cholesterol, triglyceride: HDL-cholesterol and LDL cholesterol: HDL-cholesterol were also increased (p<0.001) and apoA1: apoB were lowered (p<0.001) in patients of nephrotic syndrome.

Conclusions Therefore, there is a need to evaluate the lipid and lipoprotein levels early and so that appropriate therapy can be offered to selective candidates.