Publication:

Role of intralesional platelet-rich plasma in enhancing outcomes after internal urethrotomy for short-segment bulbar stricture

Background Internal urethrotomy is a minimally invasive treatment for urethral strictures, commonly caused by trauma or infection. Despite its simplicity, the procedure is often followed by stricture recurrence due to scar formation. Platelet-rich plasma (PRP), known for its regenerative properties in various medical fields, has shown promise in enhancing tissue healing and reducing fibrosis. This study aimed to evaluate the effect of intralesional PRP injection on stricture recurrence following internal urethrotomy. To assess the impact of submucosal intralesional PRP injection on recurrence rates after internal urethrotomy in patients with primary short-segment bulbar urethral stricture.

Methods This prospective, quasi-experimental study included 54 patients equally divided into two groups. All underwent internal urethrotomy; Group A received intralesional PRP injection, while Group B did not. PRP was prepared from autologous blood via centrifugation. Patients were followed at 3-, 6- and 9-months post-procedure to evaluate urinary flow (Qmax), post-void residual (PVR) and stsricture recurrence.

Results The mean age was comparable between groups. Inflammation was the predominant etiology. Preoperative Qmax and PVR values showed no significant differences. Postoperatively, changes in Qmax and PVR were also not statistically significant. However, stricture recurrence was significantly lower in the PRP group (0% vs. 22.2%, p<0.05). No major adverse effects were reported.

Conclusions Intralesional PRP injection following internal urethrotomy appears to be a safe and effective adjunct, significantly reducing stricture recurrence in primary short-segment bulbar urethral strictures.