Systematic ReviewInternational Journal of Basic & Clinical Pharmacology

Publication:
A systematic review on dental perspectives on pycnodysostosis

Int J Basic Clin Pharmacol. 2026;15(3):564-570.DOI10.18203/2319-2003.ijbcp20261125

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Abstract

Pycnodysostosis (PYND) is an inherited bone disorder known as autosomal recessive. Patients with this disorder can be distinguished by the presence of a height smaller than expected for adults as well as smaller limbs with other dental deformities. As this disorder is rarely diagnosed, this review aimed to highlight the various dental findings from case reports and determine the treatment for the same. To date, no definitive therapies have been developed for this disorder. New treatment modalities are needed for the disease, and proper written protocol guidelines must be adopted while treating patients from dental perspectives. Continuous medical education should be provided to undergraduate students so that they would become familiar with the disease. More large-scale clinical trials are needed to determine better outcomes in general.

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Affiliations

  1. Ajayi Michael DD, El Sobrante, California, USA
  2. Municipal Coorporation, Jalgoan, M. H., India
  3. Department of Pharmacology, JNMC, Sawangi, Wardha, M. H., India
  4. Shri K. R. Pandav Ayurveda College and Hospital, Nagpur, M. H., India
  5. Department of Molecular Biology and Genetic Engineering, PTGD Campus, RTM Nagpur University, Nagpur, M. H., India
  6. Karunya Institute of Technology, Tamil Nadu, India
  7. Adamas Consulting, Mumbai, M. H., India
  8. Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee, USA

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