Publication:

To study the association of Doppler derived indices of uterine artery resistance with composite of PIH/PET

Background Hypertensive disorders of pregnancy (HDP) are among the main public health issues worldwide. They account for an estimated 10-15% of maternal deaths globally. Among the hypertensive disorders of pregnancy, pre-eclampsia is most dangerous, occurring in 10% of first pregnancies, and in 20-25% of women with past history of hypertension. The objective of present study is to investigate the association of Doppler derived Indices of uterine artery resistance with composite of PIH/PET.

Methods A prospective follow up observational study, including pregnant women at 11-13+6 weeks of gestation in whom Uterine Artery Resistance measured using Doppler ultrasound.

Results A total of 100 subjects were enrolled, out of which 11 developed pre-eclampsia/ gestational hypertension. All Doppler indices (Resistance Index, Pulsatility Index and Systolic/Diastolic Index) had high specificities and negative predictive values.

Conclusions The potential advantages of early screening of hypertensive disorders and their associated complications may allow investigations or prophylactic interventions before 20 weeks of gestation.