Publication:

Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells

Background Breast cancer is the most common cancer disease among females in India and worldwide. This needs a critical research for finding the drugs to treat breast cancer with less side effects. The aim of the present study is to reveal the anti-proliferative effects of vanilla extract against MCF-7 cells.

Methods To reveal anti proliferative effects of vanilla leaf extract, MTT assay, cell cycle analysis and DNA fragmentation assay was performed as per standard protocols.

Results MTT assay showed decrease in cell viability with increase of dose of extract and revealed IC50 value at 31.2µg/ml. DNA fragmentation was seen in extract treated cells.

Conclusions The results of the present study confirm the antiproliferative property of vanilla leaf extract in MCF-7 cells. This study results conclude vanilla leaf extract as an effective plant source medicament for treating breast cancer.