Publication:

Hepatocellular carcinoma in eastern India, a detail analytical report from a tertiary care hospital

Background Hepatocellular carcinoma is the one of the commonest tumour worldwide.  A detailed clinical profile including its etiology and vast presentation is not available in Eastern India.

Methods Retrospective chart review of 90 patients with HCCwas done. Total 90 patients (male 81, female9)  fulfillingdiagnostic criteria for HCC adopted by Barcelona-2000 EASL conferencewere analyzed for clinical, etiological, biochemical and radiological profile.

Results Underlying cirrhosis was seen in 60% cases with Hepatitis B virus being the most common (33.3%) etiologic agent followed by Alcoholism (26.6%) in cirrhotic range. In 76.7% of HCC patients have AFP level more than 500 unit and practically diagnostic of HCC. Almost all patients presented with advanced disease (96.7%). Only 3.3% of HCC patients presented with mild disease.

Conclusions The characteristics of HCC in eastern India are somewhat different from the rest of worlds. Alcohol and HBV infection are the two most important etiology prevailing here. Keywords: HCC (Hepatocellular carcinoma), AFP (Alpha fetoprotein), HBV (Hepatitis B virus), HCV (Hepatitis C virus)