Publication:

A study to determine association of ovarian morphology with endometrial morphology and postmenopausal bleeding conducted in a tertiary care hospital

Background Postmenopausal ovaries are chiefly composed of stroma and continue to have potential for hormonal synthesis. Ovarian stromal hyperplasia and endometrial hyperplasia/cancer are often identified concurrently, suggesting that ovarian morphology may represent a marker of cancer risk among older women.

Methods An observational analytical cross-sectional study was conducted. Morphology of endometrium and ovary was studied in the specimens of total abdominal hysterectomy with unilateral/bilateral salpingo-oopherectomy in females with postmenopausal bleeding.

Results Forty two specimens of total abdominal hysterectomy with bilateral hysterectomy were studied. Age of patients ranged from 45 to 80 years. Majority of patients were in the age group 45-55 years. Average duration of menopause was 6.2 years ranging from 1.5years to 30 years. Most common endometrial pathology noted was proliferative endometrium (20, 47.6%) followed by primary endometrial malignancy and endometrial polyp (14.3%). Majority of the ovaries were unremarkable (35.8%). Most common change noted was stromal hyperplasia (31.4%).

Conclusions The study did not find statistically significant association between stromal hyperplasia/large ovary and high risk endometrial pathology.