Original Research ArticleInternational Journal of Reproduction, Contraception, Obstetrics and Gynecology
Publication: Relationship between anti-Mullerian hormone and ovarian response after using letrozole in subfertile polycystic ovary syndrome patients
Int J Reprod Contracept Obstet Gynecol. 2025;14(12):4324-4329.DOI10.18203/2320-1770.ijrcog20253905
Abstract
Background Polycystic ovary syndrome (PCOS) is the most common cause of anovulation in reproductive-age women. Anti-Mullerian hormone (AMH) was higher in PCOS women due to increased antral follicles. This study examined the relationship between Anti-mullerian hormone and ovarian response after letrozole in sub-fertile PCOS patients.
Methods This cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, BIRDEM General Hospital, Dhaka, Bangladesh, from April 2022 to September 2023. 116 sub-fertile PCOS patients receiving Letrozole were purposively selected. Patients underwent transvaginal ultrasound (TVS) and were divided into two groups by follicle size: non-responder group ( 5.1 ng/ml (OR=3.1; 95% CI (1.5-6.6), p=0.003).
Conclusion Elevated serum AMH level is a risk factor for poor ovarian response in PCOS, which may require adjusting the letrozole dosage.
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Affiliations
- Department of Obstetrics and Gynecology, Ad-Din Akij Medical College, Khulna, Bangladesh
- Department of Obstetrics and Gynecology, Sarkari Karmachari Hospital, Dhaka, Bangladesh
- Department of General Surgery, Ad-Din Akij Medical College, Khulna, Bangladesh
- Department of Obstetrics and Gynecology, East West Medical College, Dhaka, Bangladesh
- Department of Obstetrics and Gynecology, Sir Salimullah Medical College, Mitford Hospital, Dhaka, Bangladesh
- Department of Obstetrics and Gynecology, Chittagong Medical College and Hospital, Chittagong, Bangladesh
- National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh
- Department of Obstetrics and Gynecology, Sirajganj 250 Bedded General Hospital, Sirajganj, Bangladesh