Publication:

A cross-sectional observational study of coagulation profile and platelet parameters in pregnancy induced hypertension cases

Background Pregnancy-induced hypertension (PIH) is associated with significant alterations in coagulation profile and platelet parameters. Early detection of these changes can help predict complications such as preeclampsia, eclampsia, and HELLP syndrome. This study aimed to evaluate coagulation and platelet parameters in PIH and assess their correlation with disease severity.

Methods This observational study was conducted in the department of obstetrics and gynecology after institutional review board approval and informed consent. A total of 100 patients with PIH were included between December 2023 and November 2024. Coagulation parameters (PT, aPTT) and platelet indices (platelet count, MPV, PDW) were measured and compared according to disease severity.

Results The mean age of participants was 28.4 years (19-40 years), with 65% aged 25-35 years. The mean gestational age was 31.2 weeks, and most cases were diagnosed between 28-34 weeks. Primigravida women constituted 72% of the cohort. Elevated PT and aPTT levels indicated endothelial dysfunction and impaired coagulation, correlating with complications such as preeclampsia, eclampsia, and HELLP syndrome. A significant decrease in platelet count was observed, particularly in severe PIH cases. Mean Platel

Conclusions Coagulation and platelet abnormalities correlate with PIH severity and can serve as early indicators of disease progression. Routine assessment of these parameters may aid in early detection, risk stratification, and improved management, thereby reducing maternal and fetal morbidity and mortality.