Publication:

Morbidity and mortality in peptic ulcer perforations-an insights from a tertiary care center in upper Assam, India

Background Perforated peptic ulcer (PPU) is a severe and feared complication, presenting as an acute abdomen. While acid-reduction medications have contributed to a decline in perforated peptic ulcer cases. Although the incidence persists in a few rural regions in our North-East part of India. PPU significantly increases morbidity and mortality of patients. Early recognition can prevent mortality associated with delayed presentation.

Methods In the prospective observational study, 73 patients were evaluated. A detailed clinical history and examination were performed. The data was analysed using descriptive analysis( n, number of patients, in percentage % and p-value)

Results A significant increase in morbidity and mortality associated with age(p=0.03, p=0.001), shock (p=0.005,p=0.0001)), ASA (p=0.0001, p=0.0001), peritoneal contents (p=0.005, p=0.001), associated illnesses (p=0.03,p=0.001) and time of surgery (p=0.04,p=0.01) was observed respectively.

Conclusions The study highlights the significance of specific parameters in managing peptic ulcer perforation, which typically presents as an acute abdomen.