Publication:

Anticonvulsant activity of nicardipine in experimentally induced seizures in wistar albino rats.

Background The objective of the study was to evaluate the anticonvulsant activity of nicardipine in wistar albino rats.

Methods Anticonvulsant activity of nicardipine in a dose 10 mg/kg, and its effect with the standard drug lamotrigine (5 mg/kg) was studied in a maximal electroshock seizures (MES) experimental animal model.

Results Nicardipine in dose of 10 mg/kg showed significant anticonvulsant effect (p<0.001) and combination with standard drug lamotrigine (p<0.001) also showed more significant anticonvulsant effect in MES model.

Conclusions Nicardipine is having anticonvulsant activity and it also potentiates the anticonvulsant effect of lamotrigine in MES model.