Publication:

Role of immunohistochemistry in the differential diagnosis of malignant small round cell tumor: a study of 38 cases

Background : Immunohistochemistry play a very important role in modern surgical pathology especially for identification of tumors lacking the evidence of lineage differentiation on the basis of routine Hematoxylin and Eosin (H&E) stain alone. More than 90% of the tumor with diagnostic difficulties by routine H & E stain could be very well classified by using IHC. The aim of present study is to classify and identify MSRCT.

Methods The study was carried out in Department of Pathology, Government Medical College in a period from August 2008 to November 2011. Total 38 cases of MSRCT are selected for Immunohistochemical staining (IHC) and they are classified and categorized accordingly after IHC.

Results Out of 38 cases of  MSRCT, there are 18 cases (47.36%) of non-Hodgkin lymphoma, 3 (7.89%) cases of Neuroblastoma,  3 (7.89%) cases of Synovial Sarcoma, 2 (5.26%) cases of Ewing Sarcoma, 2 (5.26%) cases of Undifferentiated neuroendocrine carcinoma,  2 (5.26%) case of Desmoplastic Small Round Cell Tumor, 1 (2.63%) case of  Primitive Neuroectodermal Tumor, 1 (2.63%) case of Amelanotic Melanoma (Small cell variant), 1 (2.63%)  case of  Anaplastic Dysgerminoma, 1 (2.63%)  case of Osteosarcoma, 1 (2.63 %) case of Wilm's tumor, 1 (2.63%)  case of  Dendritic cell Tumor Testis, 1 (2.63%) case of Undifferentiated Nasopharyngeal Carcinoma, 1 (2.63%) case of  Embryonal rhabdomyosarcoma.

Conclusions IHC is very valuable tool for adequate and accurate categorization of MSRCT.