Publication:

Contralateral obstructive uropathy unveils eosinophilic solid and cystic renal cell carcinoma: a typical yet rare entity with rare presentation

The World Health Organization (WHO) 2022 kidney tumour classification has introduced a novel and uncommon type of renal cell carcinoma (RCC) known as eosinophilic solid and cystic renal cell carcinoma (ESC-RCC). ESCRCC is an under‑recognized, emerging new entity of sporadic renal neoplasms, with an approximate incidence of 0.2% of renal tumours. Approximately 70 cases have been reported in the literature till date. ESCRCC are usually seen in adult females, with a low stage and indolent behaviour, and rare incidence of recurrence or metastasis. They typically have solid and cystic morphology with very characteristic microscopy of abundant eosinophilic cytoplasm and prominent basophilic granules. They consistently harbor TSC1 or TSC2 mutations in tumour which is a proposed molecular marker for this entity. We presented hereby a case study in 56-year female with symptoms of contralateral obstructive uropathy for which patient underwent radiology and found out this tumour in opposite kidney. Uncommon gross presentation of extensive subcapsular haemorrhage and advanced TNM stage was noted in our case.