Publication:

A prospective study to determine the relationship of serum uric acid level to maternal and perinatal outcomes in patients with hypertensive disorders of pregnancy

Background To study maternal and fetal outcomes in patients with hypertensive disorders of pregnancy (According to American College of Obstetrician and Gynaecologists) by the estimation of serum uric acid levels.

Methods This is a prospective observational study conducted at tertiary hospital in Bokaro Steel city, Jharkhand over a period of 18 months. During this period women diagnosed with hypertensive disorders of pregnancy after 20 weeks (ACOG) were included. Their serum uric acid level was estimated and were divided into two groups, Group A with 60 patients with uric acid ≥6 mg/dl and Group B with 60 patients with uric acid ≥6 mg/dl. Maternal and fetal outcomes were analysed to detect differences between the two groups.

Results In Group A, 20% had gestational hypertension, 18.3% had mild preeclampsia, 41.67% had severe preeclampsia, 10% had preeclampsia superimposed on chronic hypertension and 16.7% had eclampsia. In Group B 5% had gestational hypertension, 70% had mild preeclampsia,18.3% had severe preeclampsia,5 % had preeclampsia superimposed on chronic hypertension and 1.67% had eclampsia. In group A, the mean serum uric acid (Mean±SD) of the patients were 7.3733±1.4087 mg/dl. In group B, the mean serum uric acid (Mean±SD) of the patients was 4.6633±0.6428 mg/dl. LSCS was the most common mode of delivery in group A whereas in group B majority had spontaneous onset of labour and delivered vaginally (p<0.05). Group A had adverse perinatal outcome as compared to Group B (p<0.05). Overall, Group A had adverse overall outcome as compared to Group B.

Conclusion Maternal hyperuricemia was associated with adverse maternal and perinatal outcomes in women with hypertensive disorders of pregnancy.