Publication:

A prospective study on the outcome of pregnancies with a history of prior single or multiple early pregnancy losses

Background In spite of the fact that a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of consequent pregnancy outcome isn’t clearly illustrated.

Methods A prospective observational analysis was performed on the clinical data of 100 singleton pregnant women.

Results For maternal outcomes, patients within study group delivered prior with mean gestational age and the incidences of Caesarean section and postpartum haemorrhage were higher. For placental outcomes, the incidence of placenta-mediated pregnancy complications (PMPC) within study group increased in terms of late-onset preeclampsia, oligohydramnios, early-onset fetal growth restriction, and second-trimester abortion. For perinatal outcomes, the proportion of birth abandons of newborns within study group was even higher. At last, logistic regression analyses appeared that the history of FRSA was an autonomous risk factor for caesarean section and pregnancy complications.

Conclusions Women with the history of FRSA are often exposed to an elevated incidence of maternal-placental-perinatal adverse pregnancy outcomes.