Publication:

A study on effect of vitamin d supplementation in vitamin D deficient females with polycystic ovarian syndrome

Background Polycystic ovarian syndrome is one of the most common metabolic and endocrine disorders among women, whereas vitamin D is a steroid with hormone like activity and also considered as a missing link between insulin resistance and PCOS due to its underlying mechanism of action in reducing insulin resistance thereby altering pathogenesis behind PCOS symptoms.

Methods A prospective cohort comparative observational study was carried out from July 2019 to December 2020 in 96 vitamin D deficient females with PCOS (polycystic ovarian-syndrome). All females were randomly recruited under group A and B with equal proportion of 1:1, where group A were given metformin (500 mg twice daily) only and group B were given metformin (500 mg twice daily) plus vitamin D 60000 IU weekly for 24 weeks. Baseline clinical, hormonal, metabolic, sonographic parameters were compared before and after treatment.

Results Significant improvement was seen in various parameters in both the groups, like oligomenorrhoea improved in 41.67% individuals. FG score improved from mean of 10.28±2.02 in group B to 8.44±2.23 with p<0.0001. Acne improved in both groups equally in 22.92%. Polycystic ovary pattern improved in 14.58% individuals of group B with p<0.0001. Serum total testosterone improved in 16.71% in group A and in 22.92% in group B. HOMA-IR was also reduced in both groups effectively and was statistically significant with p=0.017 in group A and p=0.001 in group B.

Conclusions Remarkable improvement was seen in clinical, hormonal, metabolic and sonographic parameters in group B and noteworthy reduction in HOMA-IR, BP and triglyceride values was also seen. Hence, supplementation of vitamin D is highly effective in improving PCOS and preventing future consequences as well.