Publication:

Role of anti-thyroid peroxidase antibodies in adverse pregnancy outcomes

Background Because of the link of thyroid auto antibodies with various pregnancy related complications and anti-thyroid peroxidase antibody (TPO Ab) being most common of all of them, can be used as a surrogate marker for thyroid related adverse pregnancy outcomes. Hence, present study was designed to further elucidate any association of anti-TPO antibodies and serum thyroid stimulating hormone (TSH) levels with adverse pregnancy outcomes.

Methods This observational study has been conducted in the department of obstetrics and gynaecology at L. L. R. M. Medical College, Meerut, Uttar Pradesh, India. Five hundred randomly selected peripartum women from 20 weeks onwards have been included and divided into two main groups, anti-TPO Ab positive (group B) and anti-TPO Ab negative (group A). Serum TSH was done only in group B. These two groups were compared for age of the patient, period of gestation, number of abortions, pregnancy outcome, maternal and fetal complications.

Results Out of 500 women, 18.6% were anti-TPO Ab positive. Number of abortions ≥ 2 was found in 18% and 8% in group B and A whereas preterm delivery was found in 50% and 17% in the two groups respectively. In group B, 48% had increased TSH.

Conclusions Anti-TPO Ab presence was significantly associated with preterm deliveries, recurrent abortions, increased maternal and fetal complications.