Publication:

A study of lipid profile in non-diabetic chronic kidney disease

Background The present study focused on finding an approximate prevalence of dyslipidemia in the target reference population and the association with staging and management strategy used. An effort was also made to know the alteration in different lipoprotein fractions in chronic kidney disease. The objective of the study was to study the lipid profile in non-diabetic patients with chronic kidney disease.

Methods The study was conducted in Ispat general hospital, Rourkela and data was collected from January 2014 to September 2015. Patients who were diagnosed with Chronic Kidney Disease admitted into the medical ward and dialysis unit of Ispat General Hospital, Rourkela, Odisha, who had willingly given their informed written consent for this study were the source of data. For diagnosis of CKD, history and clinical features with supportive biochemical and radiological evidence were taken as criteria. Patients with already known diabetes mellitus were excluded.

Results The prevalence of dyslipidemia in CKD was found to be about 65.%. And the prevalence was increasing with the increase in severity of the disease. There was a significant rise in the serum triglyceride concentration in the study population. This abnormality was followed by a fall in HDL cholesterol and rise in the total Serum cholesterol in patients suffering from CKD. On comparing patients with CKD on hemodialysis with that on conservative management there is a significant prevalence of dyslipidemia in the Hemodialysis group. There is a significantly higher level of triglycerides and Serum cholesterol and a significantly lower level of HDL cholesterol in the hemodialysis group.

Conclusions The high prevalence of lipid abnormalities in CKD may accelerate the progression of CVD and increase the mortality of patients. Hence it is worthwhile to test and detect patients at high risk early on and manage accordingly.