Publication:

Diffuse neurofibroma of the scalp: a distinct histopathological entity

Neurofibroma is a benign tumour of peripheral nerve sheath characterized by proliferation of Schwann cells, perineurial cells and endoneurial fibroblasts, involving the skin and the subcutaneous tissue in a plaque like fashion on the head and neck regions, primarily in adolescents and young adults. Different types of Neurofibromas can be identified including localized, plexiform and diffuse types. The diffuse variant is rare and distinct form, both histologically and radiologically. Excision biopsy, histopathological examination is the main diagnostic tool. S100 protein was positive. We present a case of recurrent Diffuse Neurofibroma over the Scalp in a 20 year old male patient, in the background of Neurofibromatosis 1.