Publication:

Risk factors for recurrence of invasive breast cancer after primary surgery in patients followed at the medical oncology and palliative care department of Soavinandriana Hospital Center

Background Breast cancer mortality is often linked to recurrence or progression. This study aims to identify and describe the risk factors for recurrence in invasive breast cancers after primary surgery.

Methods A case-control study was conducted from January 1, 2017, to December 31, 2023.

Results The study included 55 cases and 55 controls. Identified risk factors for recurrence include age under 50 (OR 3.21; p=0.005), partial mastectomy (OR 7.7; p=0.001), vascular emboli or perineural invasion (OR 2.85; p=0.019), poor resection margin (R+) (OR 16.36; p=0.00), >25% lymph node invasion (OR 5.33; p=0.002), capsular rupture (OR 8.78; p=0.000), CA 15-3 >30 U/ml (OR 6.66; p=0.01), and lack of radiotherapy (OR 3.39; p=0.002) or chemotherapy (OR 4.07; p=0.001) as adjuvant treatments.

Conclusions The identified risk factors align with those in existing literature and should be considered to enhance breast cancer treatment.