Publication:

Study of incidence of antiphospholipid antibody syndrome and low vitamin D levels as an etiological factor in recurrent pregnanc loss and their correlation

Background Recurrent pregnancy loss is a heterogeneous reproductive problem, with multiple etiologies. Objective of this study was to study the incidence of APLA syndrome and low vitamin d levels in RPL and correlation between APLA syndrome and low vitamin D levels.

Methods This was an observational study conducted on 110 women seen in outpatient department/inpatient department of our institution from 1st August 2015 to 31st July 2016 who were known cases of RPL who fitted our inclusion and exclusion criteria.

Results It was found that majority of the RPL patients were in the age group of 30-34 years (42.72%) and they contributed to 43% of the abortions. 77.4% abortions occurred in the gestational age of 6-8 weeks. 21.81% patients were APLA positive. 23.63% patients had  low vitamin D levels. Out of the 21.81% patients who were APLA positive (50%) also had a low vitamin D level which was found to be statistically significant.

Conclusions There appears to be some correlation between APLA syndrome and low vitamin D levels, so both have to be treated simultaneously. Properly investigating women for APLA syndrome and vitamin D deficiency would select a treatable group of women with RPL.