Publication:

Potential of Coriandrum sativum in management of diabetes and hyperlipidemia: a comprehensive review of pharmacological evidence and mechanisms

Diabetes mellitus, obesity, and hyperlipidaemia are interconnected metabolic disorders with rising prevalence worldwide, posing significant public health challenges. These conditions often coexist, forming a metabolic syndrome characterized by elevated glucose levels, excess body fat, and abnormal lipid profiles, leading to severe complications such as cardiovascular diseases and organ dysfunction. Coriandrum sativum (coriander), a culinary herb with a long history of medicinal use in traditional systems like Ayurveda, has shown promising therapeutic potential in managing these metabolic disorders. Rich in bioactive compounds such as flavonoids, polyphenols, and essential oils, coriander exhibits antidiabetic and antihyperlipidemic activities. Its efficacy has been demonstrated in various experimental models of diabetes and Hyperlipidemia, with significant reductions in blood glucose levels, lipid parameters, and oxidative stress markers. The mechanisms underlying these effects include stimulation insulin secretion, inhibition of α-glucosidase activity, modulation of lipid metabolism, and antioxidant activity. This review comprehensively evaluates the pharmacological actions and mechanisms of coriander, including its seed and leaf extracts, essential oils, and dietary incorporation, in mitigating hyperglycaemia, dyslipidaemia, and obesity-associated complications. By integrating traditional knowledge with modern scientific evidence, this article highlights the therapeutic potential of Coriandrum sativum as a natural remedy for addressing the escalating burden of metabolic disorders.