Publication:

Correlation of microalbuminuria with glycosylated haemoglobin in patients of diabetes having nephropathy

Background Diabetes mellitus is the leading cause of end stage renal disease (ESRD) and is responsible for 30-40% of all ESRD. Objectives of the study were to assess the renal functional status in diabetic nephropathy patients by evaluating and correlating glycosylated haemoglobin levels in diabetic with microalbuminuria.

Methods Present observational study was done including 75 patients having diabetic nephropathy, who attended JAH and attached groups of hospitals from May 2014 to November 2015. Detailed medical history including duration of diabetes and relevant clinical examination including glycated haemoglobin, blood urea, serum creatinine, and urinary microalbumin were recorded for each patient. All the analysis was performed using IBM SPSS Ver. 20. Significance is assessed at 5% level of significance.

Results Mean age of study population was 52.4±15.2 years with male preponderance (58.67%). Increased micturation frequency (48%) was the most common presenting symptoms. Mean fasting blood sugar (FBS), post prandial blood sugar (PPBS), HbA1c, duration of diabetes, blood pressure, microalbuminuria and serum creatinine was 151.5±48.5 mg/dL and 240.3±59.7 mg/dL, 9.03±2.1%, 9.37±5.96 years, 132±22.4/84±12.5 mmHg, 118.6±86.7 mg/day and 1.33±0.64 mg/dl respectively. Microalbuminuria (r=0.91, p≤0.05), HbA1c (r=0.67, p≤0.05) and serum Creatinine (r=0.33, p≤0.05) were positively correlated with duration of diabetes.

Conclusions Level of microalbuminuria increase with increase in duration of diabetes and worsening of diabetes.