Publication:

Effect of L-carnitine supplementation on inflammatory marker of coronary artery disease

Background L-carnitine (LC) might have the potential to control inflammation by reduction of major inflammatory cytokines, including CRP.  Therefore, this study was planned to investigate the effect of LC supplementation on CRP levels in CAD patients.

Methods 50 subjects comprised placebo group who received standard line of treatment for coronary artery disease while other 50 subjects comprised LC group who received 1000 mg of LC daily apart from standard treatment for 12 weeks. CRP levels were measured at baseline and again after 12 weeks of treatment in all subjects.

Results The participants in the LC group had significantly lower levels of CRP after 12 weeks of supplementation with LC, than at baseline (p<0.01).

Conclusions We suggest that LC supplementation, due to its antioxidant effects, have potential utility to reduce inflammation in CAD.