Publication:

Prevalence of pulmonary function abnormalities in type 2 diabetes mellitus and its association with HbA1c in nonsmokers

Background Diabetes mellitus is a chronic metabolic disorder with vast social and economic consequences an ageing population and obesity due to sedentary lifestyle are one of the foremost reasons for the development of type 2 diabetes mellitus. Aim of the current study was to ascertain the burden of respiratory function abnormalities in type 2 diabetic subjects and its correlation with symptom and hba1c in non-smokers.

Methods This cross-sectional study was conducted in KPC medical college, Jadavpur. Patients of type 2 diabetes mellitus between the age of 30-80 years fulfilling the modified Borg dyspnoea scale were included after excluding heart failure, COPD, musculoskeletal disorders. The selected subjects were then subjected to a PFT with reversibility and DLCO assessment Pattern of PFT abnormality recorded. Total of 65 subjects were chosen for the study.

Results In our study most of the patients had Restrictive abnormality Female 24 (42.9%) and male 32 (57.1%). Rest 3 (50.0%) Female patients and 3 (50.0%) male patients had Mixed abnormality. 2 (66.7%) female patients and 1 (33.3%) male patient had normal abnormality which was not statistically significant (p=0.6939).

Conclusions Pulmonary function is reduced in type 2 diabetes. Diabetes duration seems a more important influence than glycaemic control, but the definitive direction as well as the exact pathophysiological mechanism to explain this association requires further investigation.