Publication:

Comparison of effect of nifedipine, labetalol and methyldopa in treatment of hypertension in pregnancy in a tertiary care government hospital

Background To know the incidence & demographic aspects of hypertensive disorders in pregnancy and to compare effect of nifedipine, labetalol, methyldopa on various aspects of PIH such as control of BP, proteinuria, gestational age on admission & of delivery and maternal & perinatal outcome.

Methods Study was conducted in M.Y. Hospital, Indore for one year of period. Three groups each of 50 pts were given nifedipine, labetalol, and methyldopa. Groups were compared on basis of age, residence, parity, control of BP, proteinuria, gestational age of delivery maternal complication &perinatal outcome.

Results maximum patients were from younger age group and mostly are primigravida. Fall in systolic & diastolic BP is significant in all 3 groups. Incidence of decrease in albuminuria is max in labetalol group. Incidence of LSCS is maximum in nifedipine group. No statistically significant difference in three groups regarding foetal outcome.

Conclusions All three drugs are safe & effective drug in treatment of PIH. Labetalol is more effective in reducing albuminuria as compared to nifedipine & methyldopa.