Publication:

Comparative study to assess the safety of misoprostol and dinoprostone for cervical ripening and induction of labour

Background To compare safety of induction of labour with dinoprostone and misoprostol with respect to maternal complications like fever, diarrhoea, vomiting, hyperstimulation, tachysystole; and Neonatal outcomes like APGAR score of baby, meconium aspiration, birth asphyxia, hyperbilirubinemia and NICU admission.

Methods 200 Patients admitted to labour ward of Sree Gokulam Medical College and Research Foundation with an indication of induction of labour and unfavourable cervices were randomly assigned to receive either intravaginal misoprostol or intracervical dinoprostone between December 2012 and May 2014.

Results There was no significant difference in maternal or neonatal complications between the two groups. Apgar at 1 minute was significantly higher for Misoprostol group while at 5 minutes Apgar was comparable between the two groups.

Conclusions Misoprostol is as safe as dinoprostone for the induction of labour.