Publication:

Evaluation of a sunscreen for phototoxic and photo-irritant potential via photo patch testing

Background Evaluation of the potential of Venusia Sun Unseen Sunscreen to induce phototoxicity (photo irritation) in adult participants, using a photo patch test technique.

Methods This is a monocentric, non-randomised, single-application study to evaluate the potential of the Venusia sun unseen sunscreen to induce phototoxicity in adult participants, using a photo patch test technique. Two treatment sites were tested on the back of each subject and the grading was done for erythema/dryness/wrinkles (A) and oedema (O) reactions on the Draize scale. At both sites ~0.04 g of the test sunscreen was applied occlusively (T1 and T2) at visit 1. One additional site (C1) in the adjoining skin was exposed to ultraviolet (UV) light for the same period to act as a control (no product was applied on this site) for the UV exposure. At 24 hrs, T1 and C1 were UV-exposed and T1 reapplied; T2 stayed occlusive. All sites were scored at 48 hrs, with recovery confirmed at 1 week.

Results The study included 26 healthy male and female participants aged 18-65 years. At 48 hrs, mean combined phototoxicity scores (A + O) were low across sites: 0.04 at control (C1), 0.75 at UV-exposed test site (T1), and 0.96 at unexposed test site (T2). No study-related adverse events (AEs) or intolerances were reported.

Conclusions Venusia sun unseen sunscreen is well tolerated and suitable for long-term daily use, including in individuals with sensitive skin. Regular application helps reduce cumulative UV damage and lowers the risk of skin cancers.