Publication:

Evaluation of antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. in experimental animals

Background Diabetes mellitus (DM) is the most common non-communicable disease of the modern world. The study of plants having antihyperglycemic and hypolipidemic activities may give a new approach in the treatment of DM. The study was intended to evaluate the antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. (EECL) in alloxan-induced diabetic albino rats.

Methods Diabetes was induced in albino rats by administration of alloxan monohydrate (160 mg/kg, intraperitoneal). Rats were divided into six groups of six animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with 0.1 mg/kg/day of glibenclamide. Group 4, 5, and 6 received 200 and 400 mg/kg body weight of EECL. Blood samples were analyzed for blood glucose on day 1, 3, 7, 14, 21, and 28 and lipid profile on day 28.

Results The EECL showed a significant reduction (p<0.001) in blood glucose level and serum lipid profile levels with 400 mg/kg body weight in alloxan induced diabetic rats as compared with control.

Conclusion It is concluded that EECL is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats.