Publication:

Skin lesions in epidermodysplasia verruciformis and clinically mimicking many dermatological conditions

Epidermodysplasia verruciformis (EDV) is a rare genodermatosis characterized by increased susceptibility to cutaneous human papillomavirus (HPV) infection, particularly HPV 5 and 8, with a risk of malignant transformation. A 35-year-old female presented with multiple hypopigmented papules and macules over the face and upper extremities, resembling pityriasis versicolor and plane warts. Various investigations, including hemogram, serum biochemistry, viral markers and histopathological examination were conducted. Based on history and thorough examination, the case was diagnosed as EDV. The patient was treated with isotretinoin, emollients, and sunscreen, resulting in moderate improvement. Early diagnosis, sun protection, and regular dermatological follow-up are essential to prevent malignant transformation.