Publication:

Atorvastatin versus rosuvastatin in non-diabetic patients with dyslipidemia: a comparative study

Background Statins are recognized to be the first line of therapy for lowering cholesterol and have shown to reduce the morbidity and mortality caused by cardiovascular diseases. Atorvastatin and rosuvastatin are potent statins which can efficiently lower the cholesterol and triglyceride levels, we have thus undertaken this study to compare the efficacy of these two statins in non-diabetic patients.

Methods 150 patients selected for the study, were over 18 years of age with dyslipidemia with no management. Using a randomized computer table, the patients were divided into 2 groups of 75 patients each; group A, who were given atorvastatin 20 mg and group B who were given rosuvastatin 10 mg for 12 weeks. History, and blood tests for fasting blood sugar, hemoglobin A1C, lipid profile such as triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol, urea, creatinine, uric acid, creatine kinase, aspartate aminotransferase, and alanine aminotreasferase. Vitamin 25(OH) D, serum insulin and hs-CRP levels were measured after taking the base line details.

Results The numbers of women were lesser than that of men. There was a considerable reduction in the triglyceride levels, total and LDL levels in both the groups after 12 weeks of use although between the two groups there was not any significant difference. A slight reduction was seen in the hs-CRP levels and elevation in Vit D3 levels though this was not very significant due to the lesser duration of the study.

Conclusions Both atorvastatin and rosuvastatin are equally powerful statins and very effective in reducing the triglyceride and LDL-cholesterol levels. They are also effective in lowering hs-CRP and elevating vitamin D levels.