Publication:

Wound healing activity of topical phenytoin in excision wound model of Albino rats

Background Wound healing is a major medical entity. Phenytoin being an anticonvulsant drug has shown promising results in healing chronic wounds. In the present study we have evaluated the effect of topical Phenytoin on excision wound models of albino rats.

Methods Phenytoin ointment of 1%, 5% and 10% were used topically on experimental animals. Neomycin used as reference standard. In Excision wound model period of epithelialization, area of wound and hydroxyproline content were evaluated.

Results Phenytoin 1%, 5% and 10% have shown significant (P<0.001) wound healing property compared to control and Neomycin. Phenytoin hastened the wound healing compared to control and neomycin and increased hydroxyproline content of wound. Phenytoin 5% has better wound healing property compared to 1% and 10%.

Conclusions The present study has shown that Phenytoin reduces time for wound healing and improved the quality of healing tissue which provides rationale for use in chronic wound in clinical setting.