Original Research ArticleInternational Journal of Basic & Clinical Pharmacology
Publication: Investigation of the estrogenic activity of Pueraria candollei variety mirifica extract on rats
Int J Basic Clin Pharmacol. 2019;8(10):2172-2178.DOI10.18203/2319-2003.ijbcp20194255
Abstract
Background Pueraria candollei variety mirifica (PM) has been widely used as ingredient in many rejuvenating products. In this study, we aimed to assess the estrogenic activity of PM extract grown in Vietnam.
Methods Estrogenic activity of PM extract was estimated on immature female rats by using uterotrophic method to measure the weight of the reproductive organs. Estrogenic activity of PM extract also was investigated in mature female ovariectomized rats by evaluating the vaginal cells growth, reproductive organs weight, serum estradiol concentration.
Results Our results showed that PM extract at doses of 100 mg/kg, 200 mg/kg had increased the reproductive organs weight in immature rats and female ovariectomized rats. In addition, PM extract had increased the serum estradiol concentration and the vaginal cells growth by increasing the percentage of keratinocytes in female ovariectomized rats.
Conclusions Our results showed that PM extract has strong estrogenic activity in rats.
Keywords
Affiliations
- Department of Pharmacology, Hanoi University of Pharmacy, Vietnam
- Administration of Science Technology and Training, Ministry of Health, Vietnam
- Department of Pharmacology and Clinical medicine, School of Medicine and Pharmacy, Vietnam National University Ha Noi, Vietnam